adezmapimod (sb 203580) hydrochloride is a selective atp-competitive inhibitor of p38 mapk, displaying ic50 values of 50 nm for sapk2a/p38 and 500 nm for sapk2b/p38β2. this compound also inhibits lck, gsk3β, and pkbα, albeit with ic50 values 100-500 times higher than those for sapk2a/p38. additionally, adezmapimod hydrochloride acts as an activator of autophagy and mitophagy [1].
更新時(shí)間:2025-12-04