其他產(chǎn)品及廠家
nos-in-1 (2-imino-4-methylpiperidine acetate) is a potent and orally active inhibitor of no synthase (nos) isoforms. nos-in-1 exhibits ic50s of 0.1 μm, 0.2 μm, and 1.1μm for human inos (hinos), hnnos and henos, respectively.
更新時間:2025-12-04
4-chlorophenylguanidine hydrochloride is a potent inhibitor of urokinase selectivity. ?
更新時間:2025-12-04
5-fluoro 203 (nsc-703786) is a cytotoxic molecule leading to cell death by forming dna adducts. 5-fluoro 203 induces aryl hydrocarbon receptor signaling, and elevates expression of cyp1a1. 5-fluoro 203 treatment of cells also leads to elevation of reactive oxygen species and activation of p38, jnk and erk.
更新時間:2025-12-04
8-cpt-cyclic amp (8-cpt-camp) sodium functions dually as a selective activator of cyclic amp-dependent protein kinase (pka) and as a potent inhibitor of the cyclic gmp-specific phosphodiesterase (pde va), demonstrating an inhibitory concentration (ic 50) of 0.9 μm. additionally, this compound inhibits pde iii and pde iv, while significantly activating epac, showcasing its diverse pharmacological activities [1] [2].
更新時間:2025-12-04
angiotensin 1/2 + a (2 - 8) acetate is a vasoconstrictor.
更新時間:2025-12-04
sew 2871 is an orally available, highly selective s1p1 agonist with an ec50 of 13.8 nm.it reduces the number of lymphocytes in the blood and is used in studies related to diabetes, alzheimer´s disease, liver fibrosis, and inflammation. it activates erk, akt and rac signaling pathways and induces s1p1 internalization and recycling.
更新時間:2025-12-04
bay 41-8543 is a nitric oxide (no)-independent stimulator of soluble guanylyl cyclase (sgc).
更新時間:2025-12-04
brd6688 is a selective hdac2 inhibitor that acts by enhancing the learning and memory processes
更新時間:2025-12-04
sq22536 (9-(tetrahydrofuran-2-yl)-9h-purin-6-amine) , the adenosine analogue 9-(tetrahydro-2-furyl)adenine, inhibited adenylate cyclase activity of crude membrane preparations from catfish (ictalurus melas) and rat isolated hepatocytes in a non-competitive manner.
更新時間:2025-12-04
gp-82996 (cink4) is a pharmacological inhibitor specifically targeting cdk4/6, exhibiting ic50 values of 1.5 μm for cdk4/cyclin d1, 5.6 μm for cdk6/cyclin d1, and 25 μm for cdk5/p35. it effectively induces apoptosis in u2os cancer cells, positioning it as a potential investigational tool in cancer research [1] [2].
更新時間:2025-12-04
fas c-terminal tripeptide acetate shows inhibitory activity of fas/fap-1 binding.
更新時間:2025-12-04
ivermectin b1a is the major (80%) component of commercially available ivermectin and a derivative of avermectin b1a.
更新時間:2025-12-04
(±)-lisofylline is an enantiomer-specific, alkyl-substituted methylxanthine, which has specific and potent activity in down-regulating leukocyte activation. (±)-lisofylline is an anti-inflammatory agent.
更新時間:2025-12-04
veratridine is a benzoate-cevane found in veratrum and schoenocaulon. it activates sodium channels to stay open longer than normal.
更新時間:2025-12-04
nngh functions as an inhibitor of stromelysin-1 (mmp-3), which is not only a direct transcriptional target but also a vital component of the wnt/β-catenin signaling pathway. additionally, matrix metalloproteinases (mmps) are established as playing a crucial role during the later stages of tumor progression [1].
更新時間:2025-12-04
pf-9184 is a potent and selective inhibitor of human microsomal prostaglandin e synthase-1 (mpges-1), ic50 =16.5 nm. pf-9184 inhibits il-1β-induced pge2 synthesis in vitro.
更新時間:2025-12-04
quercetin (sophoretin) is a natural flavonoid and is an agonist of sirt1. quercetin is also a pi3k inhibitor, inhibiting pi3kγ, pi3kδ, and pi3kβ (ic50=2.4/3.0/5.4 μm). quercetin can induce apoptosis and autophagy.
更新時間:2025-12-04
rd162 is a non-steroidal antiandrogen (nsaa) specifically binding to the androgen receptor (ar).
更新時間:2025-12-04
beta-lipotropin (1-10), porcine acetate (beta-lipotropin ) (beta-lph) was found to contain within its c-terminal sequence the primary structure of these peptides.
更新時間:2025-12-04
terameprocol (em-1421) is a synthetic tetra-methylated derivative of nordihydroguaiaretic acid (ndga) and transcriptional inhibitor with potential antiviral, antiangiogenic, and antineoplastic activities. terameprocol showed the strongest anti-hiv activity.
更新時間:2025-12-04
vu0483605 is an effective and selective positive allosteric modulator of mglur1 with ec50s of 390 and 356 nm for human and rat, respectively.
更新時間:2025-12-04
4-iodo-saha (1k), an orally active inhibitor of both class i and class ii histone deacetylase (hdac), exhibits ec50 values of 1.1, 0.95, 0.12, 0.24, 0.85, and 1.3 μm for skbr3, ht29, u937, ja16, and hl60 cell lines, respectively. this compound holds potential for cancer research purposes [1].
更新時間:2025-12-04
a-784168, a potent and orally active inhibitor of vanilloid receptor type 1 (trpv1), acts on a ligand-gated nonselective cation channel pivotal in integrating pain stimuli including endogenous lipids, capsaicin, heat, and low ph. it demonstrates commendable central nervous system (cns) penetration upon oral administration [1].
更新時間:2025-12-04
al-8810 is an 11β-fluoro analog of pgf 2α with selective antagonist effects at the pgf 2α receptor (fp receptor) [1].
更新時間:2025-12-04
bizine, a phenelzine analogue, is a potent and selective lsd1 inhibitor, with a b>k i of 59 nm. bizine can modulate bulk histone methylation in cancer cells. bizine has potential applications in neuroprotective [1].
更新時間:2025-12-04
calindol (hydrochloride) is a positive allosteric modulator (pam) of calcimimetic calcium-sensing receptor (casr) with an ec50 of 132 nm.
更新時間:2025-12-04
2,3-butanedione 2-monoxime (diacetyl monoxime) is an inhibitor of skeletal and cardiac muscle contraction.
更新時間:2025-12-04
cog 133 acetate, (c97h181n37o19) is a peptide with the sequence ac-leu-arg-val-arg-leu-ala-ser-his-leu-arg-lys-leu-arg-lys-arg-leu-leu-amide.
更新時間:2025-12-04
ldn-211904 oxalate (compound 32), a potent and selective ephb3 inhibitor, demonstrates an ic50 of 0.079 μm and shows good metabolic stability in mouse liver microsomes. when combined with cetuximab, it may effectively inhibit stat3-activated csc stemness and cetuximab resistance in crc [1] [2].
更新時間:2025-12-04
lenalidomide hydrochloride (cc-5013 hydrochloride), a thalidomide derivative, functions as molecular glue and serves as an orally active immunomodulator. as a ligand for the ubiquitin e3 ligase cereblon (crbn), it facilitates the selective ubiquitination and degradation of the lymphoid transcription factors ikzf1 and ikzf3 through the crbn-crl4 ubiquitin ligase. specifically, lenalidomide hydrochloride inhibits the growth of mature b-cell lymphomas, including multiple myeloma, and promotes il-2
更新時間:2025-12-04
mcc-555 (isaglitazone) is a pparα and pparγ agonist exerting antihyperglycemic effects.
更新時間:2025-12-04
ml352 is a selective and potent inhibitor of the presynaptic choline transporter (cht), inhibits non-competitive choline uptake.
更新時間:2025-12-04
ms37452 is a competitive inhibitor of cbx7 chromodomain binding to h3k27me3 (ki = 43 ?m).
更新時間:2025-12-04
pf-562271 hydrochloride (pf-562271 hcl) is a potent, atp-competitive, reversible inhibitor of fak with ic50 of 1.5 nm in cell-free assays, ~10-fold less potent for pyk2 than fak and >100-fold selectivity against other protein kinases, except for some cdks.
更新時間:2025-12-04
kaempferol (robigenin) is a natural flavonoid and an inverse agonist of errα and errγ. kaempferol has a wide range of antitumor, anti-inflammatory, antioxidant, antibacterial and antiviral activities.
更新時間:2025-12-04
pyoluteorin is an antibiotic that inhibits oomycete fungi, including the plant pathogen pythium ultimum, and suppresses plant diseases caused by this fungus. pyoluteorin induces human triple-negative breast cancer mda-mb-231 cells apoptosis in vitro.
更新時間:2025-12-04
reserpine hydrochloride is an alkaloid found in the roots of rauwolfia serpentina and r. vomitoria. reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. it has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
更新時間:2025-12-04
sp 141 is a mdm2 inhibitor.sp-141 promotes mdm2 auto-ubiquitination and degradation, with anticancer activity.
更新時間:2025-12-04
tenofovir disoproxil fumarate is a nucleotide reverse transcriptase inhibitor used in the treatment of hiv and chronic hepatitis b.
更新時間:2025-12-04
(+/-)-terreic acid is a natural product found in kulturen v. aspergillus flavipes.
更新時間:2025-12-04
vu0359595 (ml-270) is a potent and selective pharmacological phospholipase d1 (pld1) inhibitor with an ic50 of 3.7 nm. vu0359595 is >1700-fold selective for pld1 over pld2 (ic50 of 6.4 μm). vu0359595 can be used for the research of cancer, diabetes, neurodegenerative and inflammatory diseases.
更新時間:2025-12-04
10-debc hydrochloride, a selective akt inhibitor demonstrating an ic50 value of 1.28 μm, is identified as a novel anti-tuberculosis compound [1] [2].
更新時間:2025-12-04
ami5 (eosin y disodium) is a versatile red dye used in cosmetics, pharmaceuticals, textiles, etc., and as tissue stain, vital stain, and counterstain with hematoxylin. it is also used in special culture media.
更新時間:2025-12-04
a 286982 is an inhibitor that blocks the integrin-ligand interaction between leukocyte function-associated antigen-1 (lfa-1) and intercellular adhesion molecule-1.
更新時間:2025-12-04
a 77636 hydrochloride is a potent, orally active, selective and long acting dopamine d1 receptor agonist (pki=7.40; ki=39.8 nm). a 77636 hydrochloride shows antiparkinsonian activity. a 77636 hydrochloride is functionally inactive at dopamine d2 receptor.
更新時間:2025-12-04
(z)-tyrphostin a51 is the z configuration of lanoconazole a51. tyrphostin a51 is a potent protein tyrosine kinase (ptk) inhibitor which inhibits the volume-sensitive release of [3 h]taurine in primary astrocyte cultures in a dose-dependent manner. tyrphostin a51 markedly reduces cellular tyrosyl phosphorylation level. tyrphostin a51 inhibits both basal and egf-induced human bone cell proliferation [1] [2].
更新時間:2025-12-04
tyrphostin ag957, a tyrosine kinase inhibitor with anti-bcr/abl tyrosine kinase activity restores beta1 integrin-mediated adhesion and inhibitory signaling in chronic myelogenous leukemia hematopoietic progenitors[1].
更新時間:2025-12-04
apogossypolone (apog2) is a semi-synthesized derivative of gossypol which is a nonpeptidic small molecule inhibitor targeting bcl-2 family proteins with k i values of 35, 25 and 660 nm for bcl-2, mcl-1 and bcl-x l, respectively. apogossypolone shows antitumor activities, induces cell apoptosis [1] and autophagy [2]. apogossypolone also has antifungal activity [3].
更新時間:2025-12-04
azepexole dihydrochloride (b-ht 933), a potent and selective alpha 2-adrenoceptor agonist, exhibits affinity for α2a-, α2b-, and α2c-adrenoceptor subtypes with pkis of 8.3, 7.6, and 7.5, respectively [1]. it elicits a concentration-dependent inhibition of peristaltic contractions, evidenced by an ic50 of 78.72 nm.
更新時間:2025-12-04
azepexole hydrochloride (4h-oxazolo[4,5-d]azepin-2-amine, 6-ethyl-5,6,7,8-tetrahydro-, hydrochloride (1:1)) is a potent α2-adrenoceptor agonist with anaesthetic effects.
更新時間:2025-12-04
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