其他產(chǎn)品及廠家
4-iodo-saha (1k), an orally active inhibitor of both class i and class ii histone deacetylase (hdac), exhibits ec50 values of 1.1, 0.95, 0.12, 0.24, 0.85, and 1.3 μm for skbr3, ht29, u937, ja16, and hl60 cell lines, respectively. this compound holds potential for cancer research purposes [1].
更新時間:2025-12-04
a-784168, a potent and orally active inhibitor of vanilloid receptor type 1 (trpv1), acts on a ligand-gated nonselective cation channel pivotal in integrating pain stimuli including endogenous lipids, capsaicin, heat, and low ph. it demonstrates commendable central nervous system (cns) penetration upon oral administration [1].
更新時間:2025-12-04
al-8810 is an 11β-fluoro analog of pgf 2α with selective antagonist effects at the pgf 2α receptor (fp receptor) [1].
更新時間:2025-12-04
bizine, a phenelzine analogue, is a potent and selective lsd1 inhibitor, with a b>k i of 59 nm. bizine can modulate bulk histone methylation in cancer cells. bizine has potential applications in neuroprotective [1].
更新時間:2025-12-04
calindol (hydrochloride) is a positive allosteric modulator (pam) of calcimimetic calcium-sensing receptor (casr) with an ec50 of 132 nm.
更新時間:2025-12-04
2,3-butanedione 2-monoxime (diacetyl monoxime) is an inhibitor of skeletal and cardiac muscle contraction.
更新時間:2025-12-04
cog 133 acetate, (c97h181n37o19) is a peptide with the sequence ac-leu-arg-val-arg-leu-ala-ser-his-leu-arg-lys-leu-arg-lys-arg-leu-leu-amide.
更新時間:2025-12-04
ldn-211904 oxalate (compound 32), a potent and selective ephb3 inhibitor, demonstrates an ic50 of 0.079 μm and shows good metabolic stability in mouse liver microsomes. when combined with cetuximab, it may effectively inhibit stat3-activated csc stemness and cetuximab resistance in crc [1] [2].
更新時間:2025-12-04
lenalidomide hydrochloride (cc-5013 hydrochloride), a thalidomide derivative, functions as molecular glue and serves as an orally active immunomodulator. as a ligand for the ubiquitin e3 ligase cereblon (crbn), it facilitates the selective ubiquitination and degradation of the lymphoid transcription factors ikzf1 and ikzf3 through the crbn-crl4 ubiquitin ligase. specifically, lenalidomide hydrochloride inhibits the growth of mature b-cell lymphomas, including multiple myeloma, and promotes il-2
更新時間:2025-12-04
mcc-555 (isaglitazone) is a pparα and pparγ agonist exerting antihyperglycemic effects.
更新時間:2025-12-04
ml352 is a selective and potent inhibitor of the presynaptic choline transporter (cht), inhibits non-competitive choline uptake.
更新時間:2025-12-04
ms37452 is a competitive inhibitor of cbx7 chromodomain binding to h3k27me3 (ki = 43 ?m).
更新時間:2025-12-04
pf-562271 hydrochloride (pf-562271 hcl) is a potent, atp-competitive, reversible inhibitor of fak with ic50 of 1.5 nm in cell-free assays, ~10-fold less potent for pyk2 than fak and >100-fold selectivity against other protein kinases, except for some cdks.
更新時間:2025-12-04
kaempferol (robigenin) is a natural flavonoid and an inverse agonist of errα and errγ. kaempferol has a wide range of antitumor, anti-inflammatory, antioxidant, antibacterial and antiviral activities.
更新時間:2025-12-04
pyoluteorin is an antibiotic that inhibits oomycete fungi, including the plant pathogen pythium ultimum, and suppresses plant diseases caused by this fungus. pyoluteorin induces human triple-negative breast cancer mda-mb-231 cells apoptosis in vitro.
更新時間:2025-12-04
reserpine hydrochloride is an alkaloid found in the roots of rauwolfia serpentina and r. vomitoria. reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. it has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
更新時間:2025-12-04
sp 141 is a mdm2 inhibitor.sp-141 promotes mdm2 auto-ubiquitination and degradation, with anticancer activity.
更新時間:2025-12-04
tenofovir disoproxil fumarate is a nucleotide reverse transcriptase inhibitor used in the treatment of hiv and chronic hepatitis b.
更新時間:2025-12-04
(+/-)-terreic acid is a natural product found in kulturen v. aspergillus flavipes.
更新時間:2025-12-04
vu0359595 (ml-270) is a potent and selective pharmacological phospholipase d1 (pld1) inhibitor with an ic50 of 3.7 nm. vu0359595 is >1700-fold selective for pld1 over pld2 (ic50 of 6.4 μm). vu0359595 can be used for the research of cancer, diabetes, neurodegenerative and inflammatory diseases.
更新時間:2025-12-04
10-debc hydrochloride, a selective akt inhibitor demonstrating an ic50 value of 1.28 μm, is identified as a novel anti-tuberculosis compound [1] [2].
更新時間:2025-12-04
ami5 (eosin y disodium) is a versatile red dye used in cosmetics, pharmaceuticals, textiles, etc., and as tissue stain, vital stain, and counterstain with hematoxylin. it is also used in special culture media.
更新時間:2025-12-04
a 286982 is an inhibitor that blocks the integrin-ligand interaction between leukocyte function-associated antigen-1 (lfa-1) and intercellular adhesion molecule-1.
更新時間:2025-12-04
a 77636 hydrochloride is a potent, orally active, selective and long acting dopamine d1 receptor agonist (pki=7.40; ki=39.8 nm). a 77636 hydrochloride shows antiparkinsonian activity. a 77636 hydrochloride is functionally inactive at dopamine d2 receptor.
更新時間:2025-12-04
(z)-tyrphostin a51 is the z configuration of lanoconazole a51. tyrphostin a51 is a potent protein tyrosine kinase (ptk) inhibitor which inhibits the volume-sensitive release of [3 h]taurine in primary astrocyte cultures in a dose-dependent manner. tyrphostin a51 markedly reduces cellular tyrosyl phosphorylation level. tyrphostin a51 inhibits both basal and egf-induced human bone cell proliferation [1] [2].
更新時間:2025-12-04
tyrphostin ag957, a tyrosine kinase inhibitor with anti-bcr/abl tyrosine kinase activity restores beta1 integrin-mediated adhesion and inhibitory signaling in chronic myelogenous leukemia hematopoietic progenitors[1].
更新時間:2025-12-04
apogossypolone (apog2) is a semi-synthesized derivative of gossypol which is a nonpeptidic small molecule inhibitor targeting bcl-2 family proteins with k i values of 35, 25 and 660 nm for bcl-2, mcl-1 and bcl-x l, respectively. apogossypolone shows antitumor activities, induces cell apoptosis [1] and autophagy [2]. apogossypolone also has antifungal activity [3].
更新時間:2025-12-04
azepexole dihydrochloride (b-ht 933), a potent and selective alpha 2-adrenoceptor agonist, exhibits affinity for α2a-, α2b-, and α2c-adrenoceptor subtypes with pkis of 8.3, 7.6, and 7.5, respectively [1]. it elicits a concentration-dependent inhibition of peristaltic contractions, evidenced by an ic50 of 78.72 nm.
更新時間:2025-12-04
azepexole hydrochloride (4h-oxazolo[4,5-d]azepin-2-amine, 6-ethyl-5,6,7,8-tetrahydro-, hydrochloride (1:1)) is a potent α2-adrenoceptor agonist with anaesthetic effects.
更新時間:2025-12-04
bd 1008 dihydrobromide is a selective antagonist of the sigma 1 (σ1) receptor (ki = 2 nm). bd 1008 dihydrobromide have high affinity for sigma1 receptors, moderate affinity for sigma2 receptors.
更新時間:2025-12-04
triptolide (pg490) belongs to the tricyclic diterpenoid group of natural products and is an inhibitor of nf-κb activation. triptolide exhibits immunosuppressive, anti-rheumatic, anti-inflammatory, anti-proliferative and anti-tumor activities.
更新時間:2025-12-04
bms 182874 hydrochloride is a nonpeptide endothelin (el) receptor antagonist.
更新時間:2025-12-04
cgp 3466b maleate (omigapil maleate) is an orally bioavailable gapdh nitrosylation inhibitor. omigapil maleate abrogates aβ1-42-induced tau acetylation, memory impairment, and locomotor dysfunction in mice. omigapil maleate has the potential for the research of alzheimer´s disease. omigapil maleate (cgp3446b maleate) is a apoptosis inhibitor. omigapil maleate can be used for the research of congenital muscular dystrophy (cmd).
更新時間:2025-12-04
crt5, a pyrazine benzamide, is a potent and selective pkd inhibitor. the vegf-induced phosphorylation of three pkd substrates (ic50s = 1, 2, and 1.5 nm for pkd1, pkd2, and pkd3, respectively), histone deacetylase 5, creb (camp-response-element-binding protein), and hsp27 (heat-shock protein 27) at ser82, is also inhibited by crt5. crt5 decreases vegf-induced endothelial migration, proliferation, and tubulogenesis[1].
更新時間:2025-12-04
dynamin inhibitory peptide acetate is a peptide with the sequence gln-val-pro-ser-arg-pro-asn-arg-ala-pro that inhibit the gtpase dynamin.
更新時間:2025-12-04
hexythiazox is a mite growth regulator and a thiazolidine based acaricide that has long-lasting effects against many kinds of mites and is applied at any stage of the plant growth from budding to fruiting.
更新時間:2025-12-04
guanylyl imidodiphosphate trisodium (guanosine 5´-[β,γ-imido]triphosphate), a non-hydrolysable gtp analogue, activates adp-ribosylation factor (arf) and strongly stimulates adenylate cyclase. it is utilized in protein synthesis studies [1] [2] [3].
更新時間:2025-12-04
gw 610 is an antitumor benzothiazole that shows growth-inhibitory activity against several cancer cell lines. in mcf-7 and mda 468 human cancer cell lines, potent antiproliferative activity (growth inhibition (gi50) < 0.1 nm) was observed.
更新時間:2025-12-04
inca-6 (triptycene-1,4-quinone) is a cell-permeable nfat inhibitor. inca-6 inhibits of cn-nfat signaling by targeting of nfat(p) substrate to the calcineurin (cn) phosphatase site.
更新時間:2025-12-04
inotilone is a major component of inonotus linteus, a traditional chinese medical herb and can be used for research of metastatic lung cancer cells.
更新時間:2025-12-04
lh-21 is a potent in vivo neutral cannabinoid cb1 receptor antagonist. lh-21 reduces food intake and body weight gain in obese zucker rats., and results in a dose-dependent inhibition of feeding [1].
更新時間:2025-12-04
lt175, a dual pparα/γ ligand, demonstrates potent insulin-sensitizing effects while exhibiting reduced adipogenic properties. this compound is an orally active partial agonist targeting pparγ, with ec50 values of 0.22 μm for hpparα, 0.26 μm for mpparα, and 0.48 μm for hpparγ. lt175 specifically interacts with pparγ, influencing the recruitment of coregulators such as the cyclic-amp response element-binding protein-binding protein and nuclear corepressor 1 (ncor1). additionally, lt175´s int
更新時間:2025-12-04
oac3 (4-fluoro-n-(1h-indol-5-yl)benzamide) is an activator of octamer-bound transcription factor 4.
更新時間:2025-12-04
ono-4817 is a broad-spectrum matrix metalloproteinase (mmp) inhibitor that potentially mitigates atherosclerotic neointimal proliferation and atheromatous plaque progression by suppressing matrix metalloproteinases (mmps). it effectively reduces the development of aortic intimal hyperplasia in experimental hyperlipidemic rabbits [1].
更新時間:2025-12-04
ono-rs-082 is a ca2+-independent phospholipase a2 inhibitor.?
更新時間:2025-12-04
oxa-01 is a potent mtorc1 and mtorc2 inhibitor, with ic 50 values of 29 nm and 7 nm, respectively [1]. oxa-01 demonstrates broad anti-tumor activity.
更新時間:2025-12-04
pregnenolone carbonitrile (5-pregnen-3β-ol-20-one-16α-carbonitrile) is an activator of rodent-pxr and induces the expression of cyp3a.
更新時間:2025-12-04
psora-4 is a potent and selective inhibitor of k v 1.3 (voltage-gated potassium channels) with a hill coefficient of 2 and an ec50 value of 3 nm [1]. psora-4 has immunosuppressive activity and inhibits proliferation of human and rat myelin-specific effector memory t cells in vitro [2].
更新時間:2025-12-04
resistomycin (geliomycin), a pentacyclic polyketide antibiotic, exhibits potent anticancer properties by triggering apoptosis.
更新時間:2025-12-04
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